王星宇，博士，副教授，硕士生导师。2014年毕业于中国海洋大学食品科学与工程学院，获食品科学工学博士学位，于2015年11月入职陕西师范大学食品工程与营养科学学院。主要从事食品功能因子和植物源天然产物消化稳定性，靶向递送载体构建，及其营养调节作用的研究。目前已经发表SCI论文30余篇，其中第一和通讯作者23篇。同时为Journal of Agricultural and Food Chemistry, Journal of Nutritional Biochemistry, Journal of Functional Foods, Food Frontiers, Analytica Chimica Acta, Phytomedicine等国际主流SCI期刊担任审稿人。参与译著《食品分析实验指导》，副主编《食品安全检测技术》两本食品专业教材。主持国家自然科学基金青年项目1项、陕西省重点研发项目2项、中央高校基本科研业务基金2项、陕西阔成检测公司横向课题1项；参与国家自然科学基金面上项目，陕西省重点研发计划和陕西省林业厅项目等共7项；授权国家发明专利3项。（以上信息截止于2026年4月）
研究方向
1. 植物源miRNA的消化稳定产生的机制及其营养调节作用。Plant miRNAs, the mechanisms behind the resistance against food digestion and their nutritional regulatory effects in the cross-kingdom fashion.
2. 天然产物通过多靶点、多通路方式预防并缓解代谢退行性疾病的发病与发展。Prophylactic and therapeutic strategies against metabolic and degenerative diseases using natural products via multi-target and multi-pathway fashions.
3. 核酸和食源性大分子对功能因子的保护机理和高稳定性高吸收率纳米载体的构建。Molecular mechanisms behind the protective effects on bioactive compounds using nucleic acids and food-derived macromolecules and the construction of nano-scale vectors for specific delivery with high stability and bioavailability.
主持项目
(1) 国家自然科学基金青年项目，31901653，植物食品miRNA在胃肠环境中的稳定性和吸收机理的研究，2020.1–2022.12，24.0万。
(2) 陕西省农业领域重点研发项目，2022NY-091，基于包涵体内特异性DNA的羊乳掺假检测技术的研发与示范，2022.1–2023.12，8.0万。
(3) 陕西省农业领域重点研发项目，2018NY-095，肉制品中食源性致病菌快速检测技术的研发与示范，2018.1–2020.12，15.0万。
(4) 中央高校项教师自由探索项目，GK202003087，荧光量子点纳米材料辅助适配体扩增检测食源性致病菌的研究，2020.01–2021.12，6.0万。
(5) 中央高校项教师自由探索项目，GK201603101，基于等温扩增的快速、可视化检测食品中有害微生物方法的研究，2016.1.1–2017.12.31，6.0万。
研究论文（*表示通讯作者）
1. Wang Jianing, Wang Zheng, Si Xiaolin, Xu Qin, Li Ying, Xin Yirao, Bai Kemeng, Qin Xinshu, Zhang Yi, Yang Xingbin, Xu Ke, Xu Ke*, Wang Xingyu*. “Green tea polyphenols inhibit the progression of colorectal cancer, the holistic mechanisms revealed by network pharmacology [J]”. Journal of Functional Foods, 2026, 141:107293. (IF: 4.4, SCI二区Top)
2. Xu Hanbo, Li Ying, Wang Jianing, Xin Yirao, Xu Qin, Qin Xinshu, Yang Xingbin, Yan Yuheng, Chen Qi, Chen Yulong, Zhang Yi, Lu Chao*, Xu Ke*, Wang Xingyu* “Astragalus membranaceus polysaccharides attenuate osteoarthritis in human primary chondrocytes and in animal model: mechanism study using RNA-seq and network pharmacology [J]”. Phytotherapy Research. 2026, 0, 1-21. (IF: 6.3, SCI二区Top)
3. Li Ying, Xu Qin, Wang Jianing, Xin Yirao, Qin Xinshu, Zhang Yi, Xu Ke*, Yang Xingbin*, Wang Xingyu*. “csi-miR166e, a microribonucleic acid of considerable abundance in plant food, ameliorates high-fat diet/streptozotocin-induced type 2 diabetes in mice via oral administration [J]”. Journal of Agricultural and Food Chemistry, 2025, 73, 23417-23434. (IF: 6.2, SCI一区Top)
4. Xu Qin, Li Ying, Qin Xinshu, Xin Yirao, Wang Jianing, Zhang Yi, Xu Ke*, Yang Xingbin*, Wang Xingyu*. “osa-miR168a, a plant miRNA that survives the process of in vivo food digestion, attenuates dextran sulfate sodium-induced colitis in mice by oral administration [J]”. Journal of Agricultural and Food Chemistry, 2024, 72, 25146-25160. (IF: 6.2, SCI一区Top)
. Li Ying, Li Yinglei, Wang Jianing, Zhang Yi, Xu Qin, Qin Xinshu, Xin Yirao, Xu Ke*, Yang Xingbin*, Wang Xingyu*. “Visualized detection of goat milk adulteration using golden nanoparticles (AuNPs) and the dilution sensitive-PCR based on supercoiled plasmids and dUTP incorporation [J]”. Journal of Food Composition and Analysis, 2024: 106249. (IF: 4.6, SCI二区Top)
6. Xu Qin, Wang Jianing, Zhang Yi, Li Ying, Qin Xinshu, Xin Yirao, Li Yinglei, Xu Ke*, Yang Xingbin*, Wang Xingyu*. “Atypical Plant miRNA cal-miR2911: robust stability against food digestion and specific promoting effect on Bifidobacterium in mice [J]”. Journal of Agricultural and Food Chemistry, 2024, 72, 4801-4813. (IF: 6.2, SCI一区Top)
7. Xu Qin, Qin Xinshu, Zhang Yi, Xu Ke, Li Ying, Li Yinglei, Qi Bangran, Li Yan, Yang Xingbin*, Wang Xingyu*. “Plant miRNA bol-miR159 regulates gut microbiota composition in mice: in vivo evidence of the crosstalk between plant miRNAs and intestinal microbes [J]”. Journal of Agricultural and Food Chemistry, 2023, 71, 16160-16173. (IF: 6.2, SCI一区Top)
8. Xu Ke, Qin Xinshu, Zhang Yi, Yang Mingyi, Zheng Haishi, Li Yinglei, Yang Xingbin, Xu Qin, Li Ying, Xu Peng*, Wang Xingyu*. “Lycium ruthenicum Murr. anthocyanins inhibit hyperproliferation of synovial fibroblasts from rheumatoid patients and the mechanism study powered by network pharmacology [J]”. Phytomedicine, 2023: 154949. (IF: 8.3, SCI一区Top)
9. Qin Xinshu, Wang Xingyu*, Xu Ke, Zhang Yi, Tian Hongye, Li Yinglei, Qi Bangran, Yang Xingbin. “Quantitative analysis of miRNAs using SplintR ligase-mediated ligation of complementary-pairing probes enhanced by RNase H (SPLICER)-qPCR [J]”. Molecular Therapy-Nucleic Acids, 2022, 31:241-255. (IF: 6.1, SCI二区Top)
10. Qin Xinshu, Wang Xingyu*, Xu Ke, Yang Xingbin, Wang Qing, Liu Chao, Wang Xinkun, Guo Xu, Sun Jinyue, Li Lin, Li Shiqi. “Synergistic antitumor effects of polysaccharides and anthocyanins from Lycium ruthenicum Murr. on human colorectal carcinoma LoVo cells and the molecular mechanism [J]”. Food Science & Nutrition, 2022, 124:1-13. (IF: 3.8, SCI二区Top)
11. Qin Xinshu, Wang Xingyu*, Xu Ke, Zhang Yi, Ren Xiaoyu, Qi Bangran, Liang Qian, Yang Xingbin, Li Lin, Li Shiqi. “Digestion of plant dietary miRNAs starts in the mouth under the protection of coingested food components and plant-derived exosome-like nanoparticles [J]”. Journal of Agricultural and Food Chemistry, 2022, 70, 4316-4327. (IF: 6.2, SCI一区Top)
12. Wang Xingyu*, Ren Xiaoyu, Ning Lufang, Wang Pengfei, Xu Ke*. “Stability and absorption mechanism of typical plant miRNAs in an in vitro gastrointestinal environment: basis for their cross-kingdom nutritional effects [J]”. Journal of Nutritional Biochemistry, 2020, 81: 108376. (IF: 4.9, SCI二区)
13. Liang Qian, Wang Xingyu*, Yang Shuo, Yu Linhong, Gao Qiaohui, Yang Xingbin, Zhao Yan. “Characterization of the antioxidative polysaccharides from Ziziphus jujube cv. Goutouzao and its tumor-inhibitory effects on human colorectal carcinoma LoVo cells via immunocyte activation [J]”. Journal of Food Biochemistry, 2020, 44(11): e13462. (IF: 4.2, SCI二区)
14. Ning Lufang, Wang Xingyu*, Xu Ke, Song Shixi, Li Qiao, Yang Xingbin. “A Novel Isothermal Method using Rolling Circle Reverse Transcription for Accurate Amplification of Small RNA sequences [J]”. Biochimie, 2019, 163:137-141. (IF: 3.0, SCI三区)
15. Song Shixi, Wang Xingyu*, Xu Ke, Ning Lufang, Yang Xingbin. “Rapid identification and quantitation of the viable cells of Lactobacillus casei in fermented dairy products using an aptamer-based strategy powered by a novel cell-SELEX protocol [J]”. Journal of Dairy Science, 2019, 102(12): 10814-10824. (IF: 4.4, SCI二区Top)
16. Song Shixi, Wang Xingyu*, Xu Ke, Xia Guanmei, Yang Xingbin. “Visualized detection of vibrio parahaemolyticus in food samples using dual-functional aptamers and cut-assisted rolling circle amplification [J]”. Journal of Agricultural and Food Chemistry, 2019, 67(4): 1244-1253. (IF: 6.2, SCI一区Top)
17. Song Shixi, Wang Xingyu*, Xu Ke, Li Qiao, Ning Lufang, Yang Xingbin. “Selection of highly specific aptamers to Vibrio parahaemolyticus using cell-SELEX powered by functionalized graphene oxide and rolling circle amplification [J]”. Analytica Chimica Acta, 2019, 1052: 153-162. (IF: 6.0, SCI一区Top)
18. Wang Xingyu, Gao Aning, Jiao Yadong, Zhao Yan, Yang Xingbin. “Antitumor effect and molecular mechanism of antioxidant polysaccharides from Salvia miltiorrhiza Bunge in human colorectal carcinoma LoVo cells [J]”. International Journal of Biological Macromolecules, 2018, 108: 625-634. (IF: 8.5, SCI二区Top)
19. Wang Xingyu, Liang Xingguo. “Azobenzene-modified antisense oligonucleotides for site-specific cleavage of RNA with photocontrollable property [J]”, RSC Advances, 2016, 6(96): 93398-93402. (IF: 4.6, SCI二区)
20. Wang Xingyu, Li Can, Gao Xiaomeng, et al. “Preparation of small RNAs using rolling circle transcription and site-specific RNA disconnection [J]”. Molecular Therapy-Nucleic Acids, 2015, 4(1): e215. (IF: 6.1, SCI二区Top)
21. Wang Xingyu, Ding Mei, Liu Zihui, Wang Dongfeng. “Synthesis of a chitosan-based functional biopolymer with both catalytic and binding groups for protein and DNA hydrolysis [J]”. RSC Advances, 2015, 5(25): 19541-19551. (IF: 4.6, SCI二区)
22. Wang Xingyu, Yu Xin, Wang Xiaoliang, Suzuki Masatomo, Asanuma Hiroyuki, Dong Ping, Wu Wei, Xingguo Liang. “Highly specific DNA detection from massive background nucleic acids based on rolling circle amplification of target dsDNA [J]”. RSC Advances, 2014, 4(72): 38293-38299. (IF: 4.6, SCI二区)
23. Wang Xingyu, Wang Dongfeng, Liang Peng, Xingguo Liang. “Synthesis and properties of an insoluble chitosan resin modified by azamacrocycle copper (II) complex for protein hydrolysis [J]”. Journal of Applied Polymer Science, 2013, 128(5): 3280-3288. (IF: 2.8, SCI三区)