个人简介
李照，博士，教授，博士生导师。2009年获得陕西师范大学化学与化工学院学士学位。2014年获得中国科学院化学研究所分析化学博士学位，师从马会民研究员。2015年起任职于陕西师范大学食品工程与营养科学学院，主要从事食品安全检测与控制研究，光学探针的设计合成及其应用的研究。2019年3月至2020年3月在美国Stanford University化学系与Steven G.Boxer院士进行合作研究，在荧光探针构建和检测方面取得了创新性研究成果。现主持国家自然科学基金面上项目，国家自然科学基金青年项目，陕西省重点研发计划项目，陕西省高校科协青年人才托举计划项目，西安市农业技术研发项目，中央高校重点项目和中央高校优秀青年团队项目等10余项。近年以第一作者或通讯作者身份在Anal.Chem.、Chem.Commun.、Biosens.Bioelectron.、J.Agric.Food Chem.和Food Chem.等国际重要学术期刊上发表学术论文40余篇，授权国家发明专利7项，科研成果获陕西省自然科学奖二等奖(第一完成人，2023年)，陕西省高等学校科学技术一等奖(第一完成人，2021年)，陕西省科技工作者创新创业大赛二等奖(第一完成人，2023年)。
近五年科研项目(10万以上)
(1)国家自然科学基金面上项目，项目号:22474071，项目起止年月:2025.01-2028.12，主持。
(2)陕西省重点研发计划项目，项目号:2022NY-038，项目起止年月:2022.01-2023.12，主持。
(3)西安市农业技术研发项目，项目号:21NYYF0053，项目起止年月:2021.10-2024.09，主持。
(4)陕西省重点研发计划项目，项目号:2018NY-099，项目起止年月:2018.01-2019.12，主持。
(5)国家自然科学基金青年项目，项目号:21605099，项目起止年月:2017.1-2019.12，主持。
(6)中央高校优秀青年创新团队项目，项目号:GK202501002，项目起止年月:2025.1-2026.12，主持。
(7)陕西省高校科协青年人才托举计划项目，项目号:20180207，项目起止年月:201801-201912，主持。
近五年代表性学术论文
(1) Qiuyue Wang, Haiyang Ji, Yitong Hao, Dongli Jia, Hongyu Ma, Changying Song, Honglan Qi, Zhao Li* and Chengxiao Zhang*. Illumination of hydroxyl radical generated in cells during ferroptosis, Arabidopsis Thaliana and mice using a new turn-on near-infrared fluorescence probe. Anal. Chem.,2024,96,20189-20196.
(2) Dongli Jia, Zhao Li*, Hongyu Ma, Haiyang Ji, Honglan Qi and Chengxiao Zhang, Near-infrared fluorescence probe with new recognition moiety for specific detection of cysteine to study corresponding physiological processes in cells,zebrafish and Arabidopsis Thaliana. Anal. Chem.,2024,96,6030-6036.
(3) Qiuyue Wang, Zhao Li*, Yitong Hao, Yuan Zhang and Chengxiao Zhang.Near-infrared fluorescence probe with new recognition moiety for specific detection and imaging of aldehyde dehydrogenase expecting the identification and isolation of cancer stem cells. Anal. Chem.,2022,94,17328-17333.
(4) Ning Ding, Zhao Li*, Yitong Hao and Chengxiao Zhang. Design of a new hydrazine moiety-based near-infrared fluorescence probe for detection and imaging of endogenous formaldehyde in vivo. Anal. Chem., 2022, 94, 12120-12126.
(5) Xinwei Tian, Zhao Li*, Yue Sun, Pan Wang and Huimin Ma*. Near-infrared fluorescent probes for hypoxia detection via joint regulated enzymes: design,synthesis, and application in living cells and mice. Anal. Chem., 2018, 90,13759-13766.
(6) Xinwei Tian, Qiuyue Wang, Jie Jian, Xingbin Yang and Zhao Li*. Small molecular organic fluorescent probes(SMOFPs) applied in food safety inspection from 2015-2025.J. Agric. Food Chem.,2025,73,19174-19203.
(7) Dongyu Li, Xinwei Tian, Zhao Li*, Jiahang Zhang and Xingbin Yang.Preparation of a near-infrared fluorescent probe based on IR-780 for highly selective and sensitive detection of bisulfite/sulfite in food, living cells and mice. J. Agric.Food Chem.,2019,67,3062-3067.
(8) Xinwei Tian, Xinxin Tong, Zhao Li*, Dongyu Li, Qingjun Kong* and Xingbin Yang. In vivo fluoride ion detection and imaging in mice using a designed near-infrared ratiometric fluorescent probe based on IR-780. J. Agric. Food Chem.,2018,66,11486-11491.
(9) Xinwei Tian, Zhao Li*, Yaxing Pang, Dongyu Li and Xingbin Yang*,Benzoyl Peroxide Detection in Real Samples and Zebrafish Imaging by a Designed Near-Infrared Fluorescent Probe. J. Agric. Food Chem.,2017,65,9553-9558.
(10) Dongyu Li, Zhao Li*, Weihua Chen and Xingbin Yang*, Imaging and detection of carboxylesterase in living cells and zebrafish pretreated with pesticides by a New near-infrared fluorescence off-on probe. J. Agric. Food Chem., 2017, 65,4209-4215.
(11) Xiaojie Tang, Yuan Zhang, Qiuyue Wang, Zhao Li* and Chengxiao Zhang,Detection of acetylcholinesterase and butyrylcholinesterase in vitro and in vivo by a new fluorescence probe. Chem. Commun.,2024,60,2082-2085.
(12) Ning Ding, Zhao Li*, Yitong Hao and Xingbin Yang*. A new amine moiety-based near-infrared fluorescence probe for detection of formaldehyde in real food samples and mice. Food Chem.,2022,384,132426.
(13) Xinwei Tian, Zhao Li*, Ning Ding and Jiahang Zhang. Near-infrared ratiometric self-assembled theranostic nanoprobe: imaging and tracking cancer chemotherapy.Chem.Commun.,2020,56,3629-3632.
(14) Ning Ding, Zhao Li*, Xinwei Tian, Jiahang Zhang, Kaili Guo and Pan Wang. Azo-based near-infrared fluorescent theranostic probe for tracking hypoxia-activated cancer chemotherapy in vivo. Chem. Commun., 2019, 55,13172-13175.
(15) Zhao Li, Xiaohua Li*, Xinghui Gao, Yangyang Zhang, Wen Shi and Huimin Ma*, Nitroreductase Detection and Hypoxic Tumor Cell Imaging by a Designed Sensitive and Selective Fluorescent Probe, 7-[(5-Nitrofuran-2-yl)methoxy]-3H-pheno-xazin-3-one.Anal.Chem.,2013,85,3926-3932.
(16) Zhao Li, Xinghui Gao, Wen Shi, Xiaohua Li and Huimin Ma*, In vivo detection and imaging of nitroreductase in zebrafish by a new near-infrared fluorescence off-on probe. Biosens. Bioelectron.,2015,63,112-116.
近五年获奖
(1)陕西省自然科学奖二等奖，2023年，食品安全危害因子快速荧光检测新策略新方法研究，主要完成人:李照，田昕伟，李东钰，张家珩。
(2)陕西省高等学校科学技术一等奖，2021年，近红外荧光探针的构建及其食品安全和肿瘤成像分析应用，主要完成人:李照，杨兴斌，田昕伟，李东钰，张家珩，丁宁。
(3)陕西省科技工作者创新创业大赛二等奖，2023年，肉“侦探”新型肉类腐败快速可视化检测产品，主要完成人:李照，马红玉，姬海洋，李雷，贾栋丽，陈梓宁，宋昌英。
近五年专利
(1)李照，唐晓洁.近红外化合物、制备方法以及丁酰胆碱酯酶检测试剂盒和应用.专利号:202210893458.9，授权公告日:2024.07.16。
(2)李照，丁宁.近红外联氨化合物、制备方法以及甲醛试剂盒和应用.专利号:202110984804X，授权公告日:2022.06.14。
(3)李照，李东钰，杨兴斌.一种测定样品中亚硫酸氢盐的检测方法及应用专利号:201710654400.8，授权公告日:2020.3.24。
(4)李照，李东钰，杨兴斌.荧光探针和基于羧酸酯酶抑制法的农药残留检测试剂盒.专利号:201610915553.9，授权公告日:2019.6.7。
(5)李照，田昕伟，杨兴斌.苯基硼酸酯化合物及包含该化合物的过氧化苯甲酰检测试剂盒.专利号:201710654441.7，授权公告日:2019.3.19。