个人简介
李婷，博士，教授，博士生导师，入选“陕西省三秦英才特殊支持计划青年拔尖人才”、“陕西省青年科技新星”和“陕西省科协青年人才托举计划”。本科毕业于西北农林科技大学，硕士毕业于陕西师范大学，2017年获香港浸会大学博士学位。主要从事膳食营养素与肠道健康、核酸营养功能、特膳食品等方面的研究工作。兼任陕西省食品科学技术学会、陕西省营养学会、陕西省饮食营养协会理事和中国农学会农产品贮藏加工分会委员，被聘为International Journal of Biological Macromolecules编委及《食品科学技术学报》青年编委。以第一或通讯作者在Cell Metabolism(第一兼通讯作者，本校独立完成，IF30.9)，Trends Food Sci Tech,JAgric Food Chem,Food Chem等国际权威期刊发表研究论文30余篇，其中1篇入选ESI高被引论文，3篇入选封面论文，单篇最高影响因子30.9。申请国家发明专利6件，出版学术著作1部，参编专业教材2部。主持国家自然科学基金面上项目、中国博士后科学基金特别资助项目、陕西省自然科学基础研究重点项目等国家级及省部级课题10余项。参与获得陕西省科技进步二等奖1项(排名5)、陕西高等学校科学技术奖一等奖(排名4)和二等奖(排名2)各1项。
近五年科研项目(10万以上)
1.国家自然科学基金面上项目，32472343，功能性寡糖触发小肠上皮细胞HSP90β-PI3K-Akt信号级联保护黏膜屏障的分子机制，2025.01-2028.12，主持
2.国家自然科学基金面上项目，32272309，功能低聚糖调控小肠上皮细胞外泌体miRNA谱的新功能及分子机制，2023.01-2026.12，主持
3.中国博士后科学基金特别资助项目，2020T130395，基于益生元水苏糖探究靶向改善肠道内环境的小肠miRNA及其分子机制，2020.01-2022.12，主持
4.国家自然科学基金青年项目，31901702，小肠上皮细胞microRNA介导水苏糖调控肠道菌群的分子机制研究，2020.01-2022.12，主持
5.陕西省自然科学基础研究计划重点项目，2025JC-QYCX-020，功能低聚糖直接作用小肠上皮细胞膜HSP90β改善肠道健康的营养新功能探究，2026.01-2022.12，主持
6.中国博士后科学基金面上项目，2019M653535，基于小肠miRNA表达谱探究水苏糖改善肠环境的分子机制，2020.01-2022.12，主持
7.陕西师范大学优秀青年人才项目，GK202309004，功能性低聚糖调控小肠外泌体miRNA谱新功能的构效关系研究，2023.01-2025.12，主持
近五年代表性学术论文
1. Li Ting*,Liu YY,Duan TC,Guo C,Liu B,Fu XQ,Wang L,Wang XY,Dong XY,Wang CN, Lu YL, Wang Y, Shi L, Tian HL, Yang XB*. Nondigesible stachyose binds membranous HSP90β on small intestinal epithelium to regulate the exosomal miRNAs: a new function and mechanism. Cell metabolism, 2025, 37(2):345-360.e6.(IF 30.9)
2. Dong XY, Liu YY, Yang XB, Li Ting*. Extracellular vesicle miRNAs as key mediators in diet-gut microbiome-host interplay. Trends in Food Science&Technology,2023,136:268-281.(IF 15.1)
3. Wang XY, Liu YY, Dong XY, Duan TC, Wang CN, Wang L, Yang XB, Tian HL,Li Ting*. peu-MIR2916-p3-enriched garlic exosomes ameliorate murine colitis by reshaping gut microbiota, especially by boosting the anti-colitic Bacteroides thetaiotaomicron.Pharmacological Research,2024,200:107071.(高被引论文，IF 9.1)
4. Hu LL, Duan TC, Hao YH, Wang CN, Wang L, Xu P, Yang X, Yang XB, Li Ting*.Dual mechanisms of raffinose in attenuating alcoholic liver injury: gut microbiota modulation and microbiota-independent bile acid pool reprogramming. Journal of Agricultural and Food Chemistry,2025,73:30316-30330(封面论文)
5. Duan TC, Alima A, Tian HL*, Li Ting*. Roundup-induced gut dysbiosis,irrelevant to aromatic amino acid deficiency, impairs the gut function in rats.Journal of Agricultural and Food Chemistry,2024,72:22822-22835.(封面论文)
6. Duan TC, Wang XY, Dong XY, Wang CN, Wang L, Yang XB, Li Ting*Broccoli-derived exosome-like nanoparticles alleviate loperamide induced constipation, in correlation with regulation on gut microbiota and tryptophan metabolism. Journal of Agricultural and Food Chemistry, 2023, 71:16568-16580.(封面论文)
7. Tan ZW, Yang CC, Zhao Y, Yang XB, Li Ting*. Interactional effects of food macronutrients with gut microbiome: implications for host health and risk.Journal of Agricultural and Food Chemistry, 2025, 73: 19109-19132.
8. Tian XW, Hu WS, Chen HY, Li Ting*, Yang XB. Nanofilm formed via amyloid-like protein aggregation for interfacial modification: prospects in food,agricultural, and beyond. Journal of Agricultural and Food Chemistry, 2025,73:29346-29359.
9. Wang XY, Liu YY, Wang Y, Dong XY, Wang CN, Wang L, Yang XB, Tian HL, Li Ting*Protective effect of coriander(Coriandrum sativum L.) on high-fructose and high-salt diet-induced hypertension: relevant to improvement of renal and intestinal function. Journal of Agricultural and Food Chemistry, 2022, 70:3730-3744.
10.Liu YY, Li Ting*, Alim A, Ren DY, Zhao Y, Yang XB*. Regulatory effects of stachyose on colonic and hepatic inflammation, gut microbiota dysbiosis, and peripheral CD4+ T cell distribution abnormality in high-fat diet-fed mice. Journal of Agricultural and Food Chemistry,2019,67:11665-11674.
11. Li Ting, Lu XS, Yang XB*. Stachyose-enriched galacto-oligosaccharides regulate gut microbiota and relieve constipation in mice. Journal of Agricultural and Food Chemistry,2013,61(48):11825-11831.
12.Zhang Y, Qi B, Li Q, Yang C, Yu P, Yang X*, Li Ting*. Dynamic changes on sensory property, nutritional quality and metabolic profiles of green kernel black beans during Eurotium cristatum-based solid-state fermentation. Food Chemistry,2024,455:139846.
13.Li Ting, Zhu J, Guo L, Shi XL, Liu YF, Yang XB*. Differential effects of polyphenols-enriched extracts from hawthorn fruit peels and fleshes on cell cycle and apoptosis in human MCF-7 breast carcinoma cells. Food Chemistry, 2013,141:1008-1018.
14.Hao YH, Wang CN, Wang L, Hu LL, Duan TC, Yang XB, Li Ting*Nondigesible stachyose alleviates cyclophosphamide-induced small intestinal mucosal injury in mice by regulating intestinal exosomal miRNAs, independently of the gut microbiota. Food Research International, 2025, 209: 116258.
15. Alim A, Li Ting*, Nisar T, Ren DY, Liu YY, Yang XB*. Consumption of two whole kiwifruit(Actinide chinensis) per day improves lipid homeostasis, fatty acid metabolism and gut microbiota in healthy rats. International Journal of Biological Macromolecules,2020,156:186.
16.Alima A, Li Ting*, Nisar T, Ali Z, Ren D, Liu Y, Yang XB*. Polyphenols and pectin enriched golden kiwifruit(Actinidia chinensis) alleviates high fructose-induced glucolipid disorders and hepatic oxidative damage in rats: in association with improvement of fatty acids metabolism. Food Science and Human Wellness,2023,12(5):1872-1884.
17.Li Ting,Fu XQ,Liu B, Wang XY,Li JK,Zhu PL, NiuXD, Bai JX, Liu YX,Lu XS, Yu ZL*. Luteolin binds Src, promotes STAT3 protein ubiquitination and exerts anti-melanoma effects in cell and mouse models. Biochemical Pharmacology,2022,200:115044.
18.Zhang XN, Li QN, Han N, Song CF, Lin YN, Zhang LS, Ren DY, Zhao Y, Yang XB* and Li Ting*. Effects of Fu brick tea polysaccharides on gut microbiota and fecal metabolites of HFD/STZ-induced type 2 diabetes rats. Food& Function,2023,14:10910-10923.
19.Wang Y, Li Ting*,Liu YY,Yang CC,Liu L,Zhang XN,Yang XB*.Heimao tea polysaccharides ameliorate obesity by enhancing gut microbiota-dependent adipocytes thermogenesis in mice fed with high fat diet. Food& Function, 2022,13:13014-13027.
20.Du HP, Wang Q, Li Ting*, Ren DY, Yang XB*. Grape seed proanthocyanidins reduced the overweight of C57BL/6J mice through modulating adipose thermogenesis and gut microbiota. Food& Function, 2021, 12(18): 8467-8477.
近五年获奖
1.陕西高等学校科学技术二等奖，功能糖与类黄酮的分子营养及互作机制研究，排名第2，2019年
2.陕西省科学技术二等奖，食物类黄酮与功能糖的化学与分子营养的应用基础研究，排名第5，2017年
近五年专利
1.一种西蓝花外泌体的提取方法及应用，ZL202310063179.4。
2.一种山楂外泌体在制备预防结肠炎药物中的应用，202512052683.6。
3.一种小鼠小肠隐窝干细胞的分离及类器官的培养方法及应用，02410356910.7。
4.一种miR-378a-5p在制备肠道健康保护产品中的应用，202510123564.2。
5.一种地黄外泌体在制备预防结肠炎药物中的应用，202610402820.6。
6.一种山药外泌体在制备预防结肠炎药物中的应用，202610421478.4。