研究工作简介

2008年7月于甘肃农业大学食品科学与工程学院获得工学学士学位，2011年7月于甘肃农业大学食品科学与工程学院获得工学硕士学位，2014年7月于西北农林科技大学食品科学与工程学院获得工学博士学位，之后于陕西师范大学食品工程与营养科学学院任职。主要从事天然食品因子的营养功能性评价及分子机制研究。

代表性成果

1.Li Yuan, Shuping Wei, Jing Wang, Xuebo Liu.Isoorientin induces apoptosis and autophagy simultaneously by ROS-related P53, PI3K/Akt, JNK and P38 signaling pathways in HepG2 cancer cells. Journal of Agricultural and Food Chemistry.2014,62(23):5390-5400.

2.Li Yuan, Yuchen Wu, Xiaomeng Ren, Qian Liu, Jing Wang, Xuebo Liu. Isoorientin attenuates lipopolysaccharide-induced pro-in?ammatory responses through down-regulation of ROS-related MAPK/NF-KB signaling pathway in BV-2 microglia. Molecular and Cellular Biochemistry. 2014, 386:153-165.

3. Li Yuan, Yutang Wang, Jing Wang, Haifang Xiao,Xuebo Liu.Additive effect of zinc oxide nanoparticles and isoorientin on apoptosis in human hepatoma cell line. Toxicology Letters. 2013,225:294-304.

4.Li Yuan, Jing Wang, Haifang Xiao, Chunxia Xiao, Wanqiang Wu, Xuebo Liu. MAPK signaling pathways regulate mitochondrial-mediated apoptosis induced by isoorientin in human hepatoblastoma cancer cells. Food and Chemical Toxicology. 2013, 53:62-68.

5.Li Yuan, Xiaomeng Ren,Yuchen Wu, Yutang Wang, Jing Wang, Haifang Xiao, Xuebo Liu.Isoorientin protects BRL-3Arat liver cell against hydrogen peroxide-induced apoptosis by inhibiting mitochondrial dysfunction, inactivating MAPKs, activating Akt and scavenging ROS and NO. Biomedicine and Aging Pathology. 2013, 3:153-159.

6. LiYuan, YangBi, Yonghong Ge, YiWang, Yaoyao Liu, GuolinLi. Postharvest hot water dipping reduces decay by inducing disease resistance and maintaining firmness in muskmelon (Cucumismelo L.) fruit.Scientia Horticulturae. 2013, 161:101-110.

7. Li Yuan, Jing Wang, Haifang Xiao, Chunxia Xiao, Yutang Wang, Xuebo Liu. Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells. Toxicology and Applied Pharmacology. 2012, 265:83-92.

8.袁莉,吴雨晨,任骁萌,刘学波.荭草素和异荭草素抗氧化活性及对肝癌细胞增殖的影响.食品科学技术学报，2013,31(6):21-27.

9.袁莉,毕阳,葛永红,王毅,李颖超,尹燕,赵阿梅.采后热处理对厚皮甜瓜贮藏品质的影响.食品科学.2010,31(20):421-424.

10.袁莉,毕阳,李永才,王毅,李颖超,尹燕,陈松江,丁波.采后赤霉素（GA3）处理对低温贮藏期间枸杞鲜果腐烂的抑制和品质的影响.食品与生物技术学报.2011,30(5).